Low-grade serous carcinoma of the ovary (LGSOC) is a distinct histological subtype of epithelial ovarian cancer. This protocol addresses recurrence therapy in patients with confirmed LGSOC, where the treatment approach differs meaningfully from high-grade serous disease.
The protocol is defined for ovarian cancer with low-grade serous carcinoma histology. Confirmation of this subtype is central to appropriate therapy selection at recurrence.
Recurrence management centres on hormonal therapy, with the specific agent guided by prior treatment history. Depending on tumour molecular characteristics, targeted therapy is also a recognised option in this setting.