Treatment of Otomycosis When Clotrimazole-Resistant Aspergillus Species Are Suspected or Isolated in the Ear

Otomycosis caused by Aspergillus species does not always respond to standard topical antifungal therapy. When clotrimazole resistance is suspected clinically or confirmed by culture, a different treatment strategy is required.

This protocol addresses the situation in which clotrimazole-resistant Aspergillus species are suspected or isolated from the ear — cases where the typical first-choice topical antifungal is unlikely to achieve adequate fungal clearance.

Management in this setting shifts to a systemic oral antifungal agent with activity against clotrimazole-resistant Aspergillus. The complete protocol — including the specific agent, dosing schedule, and treatment duration — is available in the full regimen.

Full details, including dosing and duration, are available via the link below.