Low-grade central osteosarcoma, parosteal osteosarcoma, and periosteal osteosarcoma represent distinct subtypes that follow a different clinical course from conventional high-grade disease, and their management reflects that difference.
This protocol covers patients presenting with low-grade central osteosarcoma, parosteal osteosarcoma, or periosteal osteosarcoma. These subtypes carry a lower metastatic potential, which shapes the recommended treatment strategy.
For these subtypes, the recommended approach centres on a surgical intervention. The full protocol specifies the exact parameters and any additional considerations that apply to each subtype.
DOI: 10.1038/s41416-024-02868-4
Low-grade central, parosteal and periosteal osteosarcoma have lower metastatic potential, and complete surgical removal is recommended.
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