This protocol addresses adult patients with osteomyelitis in whom bone culture has returned positive for quinolone-resistant Enterobacteriaceae. Because quinolone-class agents cannot be used in this setting, antibiotic selection must be guided by the specific culture and sensitivity results.
Quinolone-resistant Enterobacteriaceae — organisms such as Escherichia coli and related species — represent a distinct sub-population requiring a tailored approach. Evidence-based guidelines for initial antibiotic therapy in adult osteomyelitis specify antibiotic choice according to culture results, with dedicated guidance for this resistance pattern.
Initial management involves a targeted parenteral antibiotic regimen active against quinolone-resistant Enterobacteriaceae. The full structured regimen — including agent selection, dosing, and duration — is detailed in the complete protocol.