Osteomyelitis in Adults with Bone Culture Positive for Quinolone-Resistant Enterobacteriaceae
When an adult patient with osteomyelitis has a bone culture that returns positive for quinolone-resistant Enterobacteriaceae, the antibiotic regimen must be selected specifically around that resistance profile. Quinolone-based therapy is not appropriate in this setting, and a different antibiotic class is required.
Clinical Situation
This protocol applies to adults where bone culture has identified quinolone-resistant Enterobacteriaceae — organisms such as Escherichia coli — as the causative pathogen. The choice of antibiotic therapy in osteomyelitis is directly determined by culture results, and this specific resistance pattern defines a distinct treatment pathway.
Treatment Approach
Management involves intravenous beta-lactam/beta-lactamase inhibitor combination therapy selected to overcome the quinolone resistance identified in culture. The full regimen — including the specific agents, dosing, and duration — is available in the structured protocol.
References
The choice of antibiotic therapy is specific to the culture results listed in Table 3.
Initial Antibiotic Therapy for Osteomyelitis in Adults
Enterobacteriaceae (e.g., Escherichia coli), quinolone resistant