Treatment of Osteomyelitis in Adults with Bone Culture Positive for Methicillin-Sensitive Staphylococcus aureus
When an adult patient's bone culture returns positive for methicillin-sensitive Staphylococcus aureus (MSSA), antibiotic selection is guided directly by that culture result. This protocol addresses the specific regimen indicated for this organism and susceptibility profile.
Clinical scenario
Adult patient with osteomyelitis confirmed by bone culture positive for methicillin-sensitive Staphylococcus aureus. The choice of antibiotic therapy is specific to the culture results — MSSA susceptibility opens a defined set of intravenous antibiotic options distinct from those used for resistant organisms.
Treatment approach
This protocol specifies an intravenous antibiotic regimen tailored to MSSA bone infection. The full structured regimen — including which IV agent is preferred, the alternative option, and the complete dosing framework — is detailed in the protocol.
References
- The choice of antibiotic therapy is specific to the culture results listed in Table 3.
- Initial Antibiotic Therapy for Osteomyelitis in Adults
- S. aureus, methicillin sensitive
- Ceftriaxone, 2 g IV every 24 hours
- Vancomycin, 1 g IV every 12 hours
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