Treatment of Oral Lichen Planus Recalcitrant to Topical Corticosteroids
Oral lichen planus (OLP) that fails to achieve adequate control with topical corticosteroids requires a structured escalation approach. This protocol addresses that specific clinical situation, where first-line topical steroid therapy has not provided sufficient disease control.
The scenario: OLP recalcitrant to topical corticosteroids — persistent or insufficiently controlled disease despite topical steroid treatment, requiring an alternative or escalated therapeutic strategy.
When oral lichen planus does not respond to topical corticosteroids, topical calcineurin inhibitors represent an established alternative, and several systemic agents are available for more refractory cases — the complete regimen, sequencing, and criteria are set out in the full protocol.
References
DOI: 10.1111/jdv.16464
- In OLP recalcitrant to topical corticosteroids, the use of topical calcineurin inhibitors, tacrolimus and pimecrolimus, is suggested.
- Twice-daily application for 4–6 weeks has been proven safe and efficacious.
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