Managing Advanced, Inoperable, Non-Metastatic Oral Cavity Carcinoma
Clinical Scenario
This protocol addresses patients with advanced oral cavity carcinoma that is inoperable yet non-metastatic — a locally advanced presentation where surgical resection is not feasible but distant spread has not occurred. Primary radiochemotherapy is the preferred approach over radiotherapy alone in this setting, particularly in patients up to 70 years of age.
Treatment Approach (partial overview)
The protocol addresses locoregional disease control. For patients who subsequently develop a resectable locoregional recurrence, salvage surgery is a key consideration. Where prior irradiation has already been delivered and recurrence is non-resectable, re-irradiation with curative intent may be an option.
Full regimen details, sequencing, eligibility criteria, and evidence levels are available in the complete protocol.
References
- In patients with advanced, inoperable and non-metastatic oral cavity carcinoma, primary radiochemotherapy shall be preferred to radiotherapy alone, especially in the age groups up to 70 years.
- Salvage surgery should be considered in all patients with a resectable locoregional recurrence after previous radiotherapy or surgery.
- In already irradiated patients with a non-resectable locoregional recurrence, a second irradiation with curative intention should be considered.
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