Treatment of Advanced, Inoperable and Non-Metastatic Oral Cavity Carcinoma
Clinical scenario
This protocol applies to patients with advanced oral cavity carcinoma that is inoperable but has not spread to distant sites — a setting where surgery cannot be the primary treatment modality and a non-operative approach is required.
Treatment approach
Primary radiochemotherapy is the preferred strategy in this setting, particularly in patients up to 70 years of age. An alternative combined modality approach involving radiotherapy may be considered when standard chemotherapy is not suitable.
Full drug selection, dosing, sequencing, and eligibility criteria are detailed in the complete protocol →
References
In patients with advanced, inoperable and non-metastatic oral cavity carcinoma, primary radiochemotherapy shall be preferred to radiotherapy alone, especially in the age groups up to 70 years.
In the case of simultaneous primary radiochemotherapy, chemotherapy should be given with cisplatin or a cisplatin-containing combination.
As an alternative to radiochemotherapy, a combination of radiotherapy with cetuximab can be performed.
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