Oral Candidiasis That Did Not Resolve with Topical Antifungal Treatment

This protocol addresses oral candidiasis in patients where local (topical) antifungal therapy has been used and has failed to produce symptomatic response or resolution of the infection.

Previous treatment failure

The preceding line used local (topical) antifungal treatment. Escalation to this protocol is indicated when that approach did not achieve its goals: symptomatic response and resolution of oral candidiasis.

Clinical goal

Decrease of the Candida fungal infection of the oral cavity

Treatment approach

When topical therapy proves insufficient, the protocol moves to systemic antifungal therapy. The full regimen — including drug selection, dosing by candidiasis type, and titration criteria — is detailed in the structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1136/pmj.78.922.455

The appropriate dose is between 50–100 mg daily.

Patients with pseudomembranous type started with 100 mg fluconazole daily; patients with erythematous variety started with 50 mg fluconazole.

Fluconazole at doses between 50–100 mg per day is the systemic drug of choice because it has high efficacy and tolerability by the patient.

Therefore, according to the clinic and the virulence of the infection the dose would be titrated, giving good results, and increasing the guideline in those cases where the fungal infection did not decrease.

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