Treatment of Ohtahara Syndrome with Operable Structural Brain Abnormality: Hemimegalencephaly or Cortical Dysplasia

In a defined subset of patients with Ohtahara syndrome, an operable structural brain abnormality — hemimegalencephaly or cortical dysplasia — is identified. This anatomical finding changes the clinical decision-making substantially and opens a specific management pathway.

Clinical scenario

Ohtahara syndrome with an operable structural brain abnormality: hemimegalencephaly or cortical dysplasia.

Treatment approach

When a structural lesion is identified as operable, a neurosurgical approach is indicated. The choice of procedure depends on the nature and extent of the abnormality — full protocol details are available through the link below.

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References

DOI: 10.1016/j.pediatrneurol.2012.06.002

Cases with operable structural abnormalities such as hemimegalencephaly or cortical dysplasia can benefit from neurosurgical intervention with focal resection or hemispherectomy.

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