Treatment of Neurofibromatosis Type 2 with Meningioma (Intracranial or Spinal)
Clinical scenario
Neurofibromatosis type 2 is frequently complicated by meningioma development. Approximately half of NF2 patients develop meningiomas — predominantly intracranial, though spinal meningiomas are also encountered. This protocol addresses the treatment of NF2 in patients presenting with this comorbidity.
Treatment approach
Management involves surgical and non-surgical modalities; which interventions apply and how they are combined depends on tumour accessibility and resection status — the complete approach, sequencing, and full range of options are covered in the structured protocol below.
References
- About half of NF2 patients develop meningiomas, predominantly intracranial; spinal meningiomas may also be present.
- NF2 meningioma management involves possible surgery, with radiotherapy considered for surgically inaccessible or partial resection disorders.
- Targeted therapies like lapatinib and bevacizumab are also studied for NF2-associated meningioma treatment.