Clinical Scenario
This protocol addresses nasal cavity cancer where the underlying pathology is malignant melanoma or sarcoma — including mucosal melanoma and subtypes such as rhabdomyosarcoma. Malignant melanoma presents in less than 1% of neoplasms in this region. Lymphomas, sarcomas, and mucosal melanomas of the paranasal sinuses and nasal cavity are not staged using the standard staging system for this region, and their management reflects distinct histology-specific pathways.
Treatment Approach — Partial Overview
When surgically feasible, the approach centres on excision. In cases where surgery is not possible, radiation therapy is among the options considered. For certain sarcoma subtypes, a combined modality approach involving surgery, radiation, and systemic therapy is recommended. The full algorithm — including specific agent selection, sequencing, and stage-dependent considerations — is available in the complete protocol.
Full regimen detail, sequencing, and agent selection available below ↓
References
Malignant melanoma presents in less than 1% of neoplasms in this region.
Lymphomas, sarcomas, and mucosal melanomas of the paranasal sinuses and nasal cavity are not staged using this system.
Surgical excision if possible; otherwise, consider radiation therapy.
Combined surgery, radiation therapy, and chemotherapy are recommended for rhabdomyosarcoma.
Appropriate radiation therapy and various chemotherapy agents should be considered.
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