Treatment of Nasal Cavity Cancer in Low- or Intermediate-Grade Sinonasal Tumour

Clinical Scenario

This protocol is for patients with nasal cavity cancer whose histology shows a low- or intermediate-grade sinonasal tumour, or a well-differentiated sinonasal tumour. In this tumour grade profile, neoadjuvant chemotherapy is not considered suitable, and the recommended treatment pathway differs from higher-grade presentations.

Treatment Approach (partial overview)

First-line therapy for this scenario centres on a surgical approach aimed at achieving complete resection with negative margins. The operative technique and intraoperative margin assessment are central to guiding this intervention.

The full surgical options, approach selection criteria, and evidence-graded recommendations are detailed in the structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.esmoop.2024.104121

When NACT is not suitable (e.g. low- or intermediate-grade tumours, well-differentiated tumours), surgery with resection in negative margins is indicated as first-line therapy.

Surgery is recommended only when complete resection appears feasible, especially for early stage [III, A], but also for later-stage tumours [III, B].

Intraoperative assessment of the surgical margins of frozen tissue sample sections from the periphery of the resection is strongly recommended [IV, A].

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