Mycosis fungoides at clinical stage IVA or IVB represents advanced disease. This page outlines the clinical scenario and provides a brief orientation to the treatment approach. Full regimen detail is available via the link below.
This protocol applies to patients with mycosis fungoides who have reached clinical stage IVA or IVB — advanced disease defined by significant systemic involvement, including lymph node disease, visceral spread, or a high burden of circulating tumour cells in the blood. Both stage IVA and IVB are addressed; for stage IVA1 specifically, guidance applicable to Sézary syndrome may also be relevant.
For advanced-stage mycosis fungoides, multiple treatment categories are considered equivalent rather than ranked by line — encompassing systemic chemotherapy approaches, radiation-based modalities, and targeted agents available under specific clinical conditions. The full protocol details the complete option set, selection criteria, and sequencing considerations.
DOI: 10.1016/j.ejca.2023.113343