Treatment of Multiple System Atrophy Complicated by Dystonia — Involuntary Contraction of Agonist and Antagonist Muscles

Dystonia is a recognised extrapyramidal complication in patients with multiple system atrophy. It presents as involuntary co-contraction of agonist and antagonist muscles, producing abnormal posturing, twisting, and repetitive movements that can significantly affect function.

For focal presentations of dystonia in MSA, a targeted, locally-administered biological therapy is among the options considered. The complete structured regimen — including eligibility, sequencing, and clinical endpoints — is available via the protocol.