Treatment of Multiple System Atrophy in Patients with Dystonia

Dystonia is a recognised extrapyramidal complication of multiple system atrophy that adds significant clinical burden and warrants targeted management.

This protocol applies to patients with multiple system atrophy who present with dystonia — involuntary co-contraction of agonist and antagonist muscles producing abnormal posturing, twisting, and repetitive movements.

Symptomatic management of dystonia in this setting involves pharmacological intervention — anticholinergic agents are among the options considered. The complete selection criteria, sequencing, and regimen details are available in the full protocol.

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References

Dystonia, an involuntary contraction of agonist and antagonist muscles resulting in abnormal posturing, twisting, and repetitive movements, is a common extrapyramidal symptom in patients with multiple system atrophy.

Symptomatic relief of dystonia has also been reported with anticholinergics, amantadine, dopamine agonists, and muscle relaxants.

DOI: 10.1212/cont.0000000000001598

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