Multiple system atrophy
ICD-10 G23.2; G23.3 · ICD-11 8D87.0

Treatment of Multiple System Atrophy with Dystonia

Clinical Scenario

This protocol addresses patients with multiple system atrophy who develop dystonia — the involuntary co-contraction of agonist and antagonist muscles resulting in abnormal posturing, twisting, and repetitive movements.

The Situation

Dystonia is a common extrapyramidal symptom in patients with multiple system atrophy. It arises from involuntary contraction of agonist and antagonist muscles simultaneously, producing characteristic abnormal posturing, twisting, and repetitive movements. Identifying contributing factors is a key step in management.

Treatment Approach (Partial Overview)

When dystonia in the setting of multiple system atrophy is linked to dopaminergic therapy, a structured medication review forms a central part of the protocol

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1212/cont.0000000000001598

Dystonia, an involuntary contraction of agonist and antagonist muscles resulting in abnormal posturing, twisting, and repetitive movements, is a common extrapyramidal symptom in patients with multiple system atrophy.

Some of these symptoms can be induced by dopaminergic medications (eg, levodopa or dopamine agonists), and dosage reduction or discontinuation of the medication may be needed after performing a risk-benefit assessment.

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