Treatment of Multiple Sclerosis in Clinically Isolated Syndrome with Abnormal Brain MRI Lesions

A first demyelinating episode — a clinically isolated syndrome (CIS) — accompanied by brain MRI findings consistent with multiple sclerosis represents a distinct clinical situation. When the patient has CIS with abnormal MRI lesions suggestive of MS but does not yet meet the full diagnostic criteria for MS, specific management is indicated.

Clinical scenario Clinically isolated syndrome; abnormal brain MRI with lesions suggestive of multiple sclerosis; patient does not fulfil the diagnostic criteria for multiple sclerosis.

Treatment approach (partial)

An interferon-based disease-modifying therapy is among the options considered in this setting. The full structured regimen — including all recommended agents, selection criteria, and sequencing — is available in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

Offer interferon or glatiramer acetate to patients with CIS and an abnormal MRI with lesions suggestive of MS who do not fulfil criteria for MS.

DOI: 10.1177/1352458517751049

View source ↗