In Multiple endocrine neoplasia type 2B (MEN2B), medullary thyroid carcinoma can spread to the lungs or mediastinum. This page outlines the clinical context and the direction of management for this specific metastatic scenario.
This protocol covers MEN2B presenting with medullary thyroid carcinoma complicated by lung metastasis or mediastinal metastasis. Lung metastases in this setting are usually multiple and are often associated with mediastinal lymph node metastases.
Management is guided by the characteristics of the metastatic disease and may involve interventional or systemic strategies depending on the presentation. The complete protocol specifies the criteria that determine which approach applies and in what sequence.
DOI: 10.1089/thy.2014.0335
Lung metastases are usually multiple and often associated with mediastinal lymph node metastases.
Surgical resection should be considered in patients with large solitary lung metastases.
Radiofrequency ablation should be considered when the metastases are peripheral and small.
Systemic therapy should be considered in patients with multiple metastases that are progressively increasing in size.
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