This protocol addresses MEN2B presenting in the context of medullary thyroid carcinoma (MTC) complicated by liver metastasis — a clinically significant scenario that requires specific hepatic management strategies distinct from the primary thyroid disease.
Clinical scenario: Medullary thyroid carcinoma with liver metastasis. Liver metastases occur in 45% of patients with advanced MTC, representing a well-recognised and consequential complication in this disease.
Management of hepatic metastases in this setting centres on targeted hepatic interventions — with the choice of approach guided by the pattern and extent of liver involvement. The complete criteria, sequencing, and full structured protocol are available via the link below…
Liver metastases occur in 45% of patients with advanced MTC.
Surgical resection should be considered in patients with large isolated hepatic metastases.
Chemoembolization should be considered in patients with disseminated tumors less than 30 mm in size involving less than a third of the liver.
DOI: 10.1089/thy.2014.0335
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