Treatment of Multiple Endocrine Neoplasia Type 2B in Medullary Thyroid Carcinoma with Cutaneous Metastasis

This protocol addresses Multiple endocrine neoplasia type 2B (MEN2B) in the specific setting of medullary thyroid carcinoma (MTC) that has spread to the skin. Cutaneous metastases are an uncommon complication of MTC, and their presence defines a distinct clinical situation that calls for a dedicated management approach.

Depending on the number and distribution of cutaneous lesions, local interventional strategies directed at the skin metastases form the basis of management. The specific modalities selected and the sequence in which they are applied depend on the clinical details of each case.

The complete evidence-based regimen, decision criteria, and full algorithm are available in the structured protocol below.