Treatment of Multiple Endocrine Neoplasia Type 2A with Lung Metastases and Mediastinal Lymph Node Involvement

This protocol addresses the management of Multiple endocrine neoplasia type 2A (MEN2A) in patients presenting with pulmonary metastases and mediastinal lymph node metastases arising from medullary thyroid carcinoma.

Clinical Scenario

Lung metastases in the setting of medullary thyroid carcinoma are frequently multiple and are often found together with mediastinal lymph node metastases, reflecting the spread pattern of this disease.

Treatment Approach — Overview

The therapeutic strategy is determined by the number, size, and location of the pulmonary lesions. Depending on these characteristics, the approach may involve a local interventional option or a systemic strategy.

Full eligibility criteria, sequencing, and all options are in the structured protocol ↓

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1089/thy.2014.0335

Lung metastases are usually multiple and often associated with mediastinal lymph node metastases.
Surgical resection should be considered in patients with large solitary lung metastases.
Radiofrequency ablation should be considered when the metastases are peripheral and small.
Systemic therapy should be considered in patients with multiple metastases that are progressively increasing in size.

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