Multiple Endocrine Neoplasia Type 2A in Cutaneous Lichen Amyloidosis with Pruritus

Patients with Multiple endocrine neoplasia type 2A (MEN2A) may present with cutaneous lichen amyloidosis (CLA), a skin manifestation characterised by intense, persistent pruritus predominantly affecting the scapular region of the back, spanning dermatomes T2–T6.

The hallmark of this presentation is intense pruritus in the scapular region. The classic symptom of CLA is pruritus that improves with sun exposure and characteristically worsens during periods of stress. Recognition of CLA in the MEN2A context is clinically significant and calls for a structured, protocol-driven management approach.

Treatment Overview

Management targets relief of the pruritus through topical therapies, with further options detailed in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1089/thy.2014.0335

The classic symptom of CLA is intense pruritus that improves with sun exposure and worsens during periods of stress.

Moisturizing lotions and creams, local corticosteroids, systemic antihistamines, and phototherapy usually provide incomplete symptom relief of the pruritus.

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