Treatment of MGUS with Recurrent Infections

This protocol addresses patients with monoclonal gammopathy of undetermined significance (MGUS) who have a history of frequent, recurrent, or persistent infections. The immune changes that accompany MGUS can increase susceptibility to infection, making this a clinically important complication that warrants a targeted management approach.

The protocol involves preventive and early-response strategies directed at the elevated infection risk in this population — including timely use of antibiotics and immunisation measures. The complete structured regimen, including full sequencing and specialist referral criteria, is available in the full protocol.