Mitral regurgitation
ICD-10 I34.0 · ICD-11 BB61

Treatment of Severe Ventricular Secondary Mitral Regurgitation with Concomitant Coronary Artery Disease Requiring Revascularization

Clinical Scenario

This protocol addresses patients presenting with severe ventricular (secondary/functional) mitral regurgitation in the context of concomitant ischemic heart disease — specifically, coronary artery disease that independently requires revascularization. The co-existence of these two conditions determines how mitral valve management is integrated with coronary intervention.

Key Condition: Ischemic Heart Disease

Severe ischaemic ventricular secondary MR alongside CAD requiring coronary revascularization defines this population. Patient surgical risk profile and coronary anatomy are the pivotal factors that guide the choice of strategy.

Management Approach (Partial Overview)

The recommended pathway coordinates mitral valve intervention with coronary revascularization. For appropriate candidates, a surgical strategy addressing both conditions together is the primary recommendation. Where surgical risk is elevated or the coronary anatomy favours a percutaneous approach, an alternative catheter-based option for the mitral valve — undertaken after re-evaluation — may be considered.

Patient selection criteria, procedural sequencing, and the full decision algorithm are available in the complete structured protocol.

Instant Access to Structured Evidence-Based Regimens
References
DOI: 10.1093/eurheartj/ehaf194
In patients with severe ischaemic ventricular SMR and concomitant CAD requiring coronary revascularization, MV surgery at the time of CABG is recommended, unless the patient is at high surgical risk and/or the coronary anatomy is suitable for PCI.
MV surgery is recommended in patients with severe ventricular SMR undergoing CABG.
PCI followed by TEER after re-evaluation of MR may be considered in symptomatic patients with chronic severe ventricular SMR and non-complex CAD.
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