What Is the First-Line Treatment for Minimal Change Disease?

Minimal change disease (MCD) presents with nephrotic-range proteinuria and requires prompt, structured first-line therapy. Selecting the right initial approach and knowing when to expect a response are key to achieving remission.

First-line management is centred on a structured course of high-dose oral glucocorticoid therapy, applied within a defined duration framework to limit cumulative exposure. The complete regimen — including dosing strategy, remission criteria, and tapering schedule — is detailed in the full protocol.