This protocol covers the management of malignant peripheral nerve sheath tumour (MPNST) arising in the head and neck — a site that introduces specific anatomical constraints that shape the treatment approach.
Head and neck MPNST presents particular resectability challenges: loco-regional anatomy and critical surrounding structures can make achieving complete (R0) surgical resection technically difficult. This anatomical context directly influences how the treatment plan is structured.
In patients with MPNST of the head and neck, the approach involves surgical management combined with adjuvant therapy. The complete protocol — including the specific sequence, selection criteria, and all clinical considerations — is available in the full structured regimen below.
DOI: 10.3390/cancers16193266
In head and neck MPNSTs, R0 resection may be challenging as a result of loco-regional anatomy and critical surrounding structures.
In this subset of patients, the optimum choice of treatment may be surgery with adjuvant therapy.
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