Malignant peripheral nerve sheath tumor
ICD-10 C47 · ICD-11 2B5E

Locally Recurrent Malignant Peripheral Nerve Sheath Tumor with Macroscopic Residual Disease

This protocol addresses malignant peripheral nerve sheath tumor that has recurred locally, with macroscopic tumour remaining or recurring in the tumour bed — a clinically distinct situation requiring a specific, structured approach.

Clinical Scenario

Locally recurrent MPNST in which macroscopic disease is present or re-emerging at the original tumour site. The defining feature is visible gross tumour in the tumour bed, which drives the management decision.

Approach (partial overview)

Management centres on surgical re-intervention targeting the recurrence, combined with adjuvant treatment aimed at reducing the risk of further relapse. The complete eligibility criteria, sequencing, and clinical considerations are contained in the full structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.3390/cancers16193266

There is the consideration of re-resection if there is an apparent macroscopic tumour remaining/recurring in the tumour bed.

Almost two-thirds of the patients (64.9%) had surgery for their recurrence.

The use of RT reduced the risk of relapse.

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