This protocol addresses patients with a localized malignant peripheral nerve sheath tumour (MPNST) in whom there is no evidence of distant metastasis. In this setting, complete surgical excision with clear margins is a pivotal element of potentially curative management.
Treatment approach
The systemic treatment strategy involves peri-operative chemotherapy combining an alkylating agent with an anthracycline, considered on an individual case-by-case basis. The full regimen — including agent selection, sequencing, and all decision criteria — is detailed in the structured protocol.
Complete regimen, dosing criteria, and clinical algorithm available below →