Clinical Scenario

This protocol addresses patients with a localized malignant peripheral nerve sheath tumor (MPNST) where imaging confirms no distant metastasis. Complete surgical excision with clear margins is a pivotal element of potentially curative management in this setting.

Treatment Approach

In addition to surgery, the management of localized MPNST may incorporate external radiotherapy — particularly for tumours that are large, high-grade, or where surgical margins are not clear. The full protocol specifies the clinical criteria that guide its use and timing.

Complete regimen details, criteria, and sequencing available via the link below →

References

DOI: 10.3390/cancers16193266

For localized MPNST, complete surgical excision with clear margins is a pivotal element of potentially curative management.
Pre- or post-operative radiotherapy has a significant role in localized disease by reducing the risk of local relapse in MPNSTs of the extremities, trunk or head and neck, especially when there are close margins or R1 on the surgical specimen.
The usual dose of RT delivered was often in excess of 50 Gray (Gy) via different types of external RT.
The literature generally recommends that RT is most useful in patients with large (>5 cm), high-grade tumours and/or those with R1 resections.

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Treatment of Localized Malignant Peripheral Nerve Sheath Tumor Without Distant Metastasis

Clinical Scenario

Treatment Approach

References