Treatment of Advanced-Stage (T3/T4) Lip Cancer at the Commissure
This protocol addresses larger, advanced-stage malignant neoplasms of the commissure of lip — tumours exceeding 4 cm in greatest dimension (T3 or T4) that require reconstruction.
Larger lesions of the lip require more consideration with regard to reconstruction techniques. Five-year crude survival rates for surgical treatment drop substantially at T3 and T4 staging compared with earlier-stage disease.
Post-Surgical Management
Following resection, adjuvant therapy directed at the operative site may be indicated. The full structured protocol specifies the criteria and approach for post-operative adjuvant treatment in the presence of unfavourable disease factors.
Full regimen details, sequencing, and decision criteria available via the protocol below.References
DOI: 10.1017/S0022215116000499
Larger lesions of the lip require more consideration with regard to reconstruction techniques.
The five-year crude survival rates for surgical treatment are about 75–80 per cent for T1 to T2 tumours, dropping to 40–50 per cent for T3 and T4 tumours.
Post-operative adjuvant radiation or radiochemotherapy should be considered in the presence of unfavourable disease factors.
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