This scenario applies to a patient with no personal history of colorectal or another cancer, whose family history is suggestive of Lynch syndrome and who has a first-degree relative with a confirmed Lynch syndrome mutation.
The patient carries no prior cancer diagnosis. A first-degree relative has a known Lynch syndrome mutation, and the broader family history raises clinical concern for Lynch syndrome. In this context, proactive evaluation is recommended rather than an expectant approach.
DOI: 10.1053/j.gastro.2015.07.036
In patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome, the AGA suggests that risk prediction models be offered rather than doing nothing.
If there is a first-degree relative with a known Lynch syndrome mutation, the AGA recommends that the patient be offered germline genetic testing for that mutation.
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