What Is the Treatment for Lupus Profundus?

Lupus profundus is a form of cutaneous lupus erythematosus affecting the deep dermis and subcutaneous tissue. This page summarises the evidence-based treatment approach; the full structured protocol is available via the link below.

Treatment Approach

The recommended regimen centres on an oral immunosuppressant — MMF, or MPA as an alternative — used preferably in combination with antimalarials. The complete dosing sequence, escalation thresholds, and decision criteria are detailed in the full protocol.

Full regimen, dosing schedule, and clinical algorithm available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

We recommend MMF as third-line treatment in refractory CLE patients, preferably in addition to antimalarials.
We recommend 2 x 500 mg MMF per day as starting dose that can be increased up to 3 g per day depending on the clinical response.
We suggest MPA as an alternative treatment to MMF.

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