Lupus profundus requires a structured topical treatment approach matched to lesion activity and location. The initial line of management centres on topical agents, with the choice of agent guided by the nature of the lesions.
First-line management involves a time-limited course of topical corticosteroids applied to affected lesions. Where lesion characteristics or site call for an alternative, a different class of topical agent may be used as an initial or subsequent option — the complete selection criteria and sequencing are in the full protocol.