Treatment of Lupus Pernio When Initial Therapy Is Insufficient or Causes Toxicity
This protocol addresses management of lupus pernio in the setting where the initial therapeutic approach has failed to achieve an adequate response or has led to toxicity, warranting escalation of treatment.
Treatment Approach
The structured protocol for this scenario involves adding an antimalarial agent and/or a cytotoxic drug. The specific agent selection, sequencing, and criteria for choosing among the available options are detailed in the full evidence-based regimen.
References
If toxicity/failure of the above therapy: add hydroxychloroquine and/or cytotoxic drug.
Cytotoxic drugs include: methotrexate, azathioprine, mycophenolate and leflunomide.
View source ↗