Treatment of Lobular Carcinoma In Situ of the Breast Associated with Atypical Ductal Hyperplasia or Non-Classic LCIS

Clinical Scenario

This protocol addresses lobular neoplasia — including classic lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) — when it is found alongside other high-risk breast lesions such as atypical ductal hyperplasia (ADH) or non-classic LCIS.

      The co-occurrence of lobular neoplasia with ADH or non-classic LCIS identifies a subgroup at elevated risk of an underlying higher-grade lesion, warranting a more active surgical approach than surveillance alone.
    

Management Approach

The recommended intervention involves a surgical procedure targeting the affected breast tissue. The full protocol — including the precise procedural indication, extent of excision, and any additional management steps — is detailed in the complete regimen.

Full algorithm, sequencing, and procedural specifics available via the link below.

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References

When LN is associated with other high-risk lesions such ADH and non-classic LCIS, excisional biopsy is recommended due to an upgrade rate of at least 25%.

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