This protocol addresses classic lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (ALH) found incidentally — where there is radiologic-pathologic concordance and no other associated high-risk lesion is present (no atypical ductal hyperplasia, no non-classic LCIS).
Classic LCIS and ALH are characterised by e-cadherin negative, discohesive cells in the terminal ductal lobular unit (TDLU). These findings are typically encountered incidentally when biopsy was performed for a separate imaging target rather than as the primary lesion of concern.
In this setting, a surgical approach to the breast lesion may be warranted depending on the specific clinical and radiologic circumstances. The full protocol details the precise indications and conditions under which intervention is recommended.