Treatment of Liver Cirrhosis in Hepatopulmonary Syndrome with PaO₂ Below 60 mmHg

This protocol applies to patients with liver cirrhosis who have developed hepatopulmonary syndrome (HPS) and present with a partial pressure of arterial oxygen (PaO₂) below 60 mmHg, indicating severe hypoxaemia in the setting of advanced liver disease.

Hepatopulmonary syndrome is the defining concurrent condition in this scenario. Patients with HPS and PaO₂ <60 mmHg require specific clinical evaluation, as standard medical management of cirrhosis alone is insufficient to address this complication.

The evidence-based approach in this setting centres on a definitive surgical procedure targeting the underlying liver pathology. This is the only intervention that has been proven effective for HPS to date. Full eligibility criteria, evaluation pathway, and clinical decision steps are available in the complete protocol.