What is the first-line treatment of Listerial meningitis?
Clinical scenario
This protocol addresses confirmed Listerial meningitis in adults requiring first-line antibiotic treatment. The goal is to guide selection of appropriate intravenous therapy and ensure timely specialist involvement.
Treatment approach
First-line management centres on intravenous antibiotic therapy. Early consultation with an infection specialist is recommended to evaluate the need for additional antibiotic coverage during the initial treatment phase.
Full drug selection, specialist review criteria, and the complete treatment algorithm are available in the structured protocol below.
Clinical goal
Treatment aims for confirmed clinical recovery by the end of the full antibiotic course.
Recovery endpoint defined in full protocol
References
- Give intravenous amoxicillin or ampicillin for 21 days.
- Get advice from an infection specialist on adding intravenous co-trimoxazole for the first 7 days.
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