Treatment of Localised, Clinically Resectable High-Grade (Grade 2–3) Liposarcoma of the Extremity or Superficial Trunk

This protocol addresses the management of localised liposarcoma that is clinically resectable and classified as high-grade (grade 2–3), arising from an extremity or the superficial trunk — a specific sub-population where the interplay between surgical and adjuvant modalities is central to the treatment approach.

Clinical scenario

Localised, clinically resectable, high-grade (grade 2–3) liposarcoma of an extremity or superficial trunk. The resectable nature of the disease and the high-grade histology together define the management framework for this group.

Approach — partial summary

Management of local relapse in this setting parallels the approach to primary local disease, centred on surgical resection, with broader consideration of perioperative radiation and/or systemic therapy when these have not previously been administered. The full structured regimen — including sequencing, modality selection criteria, and further details — is available in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.annonc.2021.07.006

Localised, clinically resectable, extremity and superficial trunk STS
Grade 2-3
The standard approach to local relapses parallels the approach to primary local disease, except for a wider utilisation of preoperative or post-operative RT and/or ChT, if not previously administered.

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