Treatment of Localised, Resectable High-Grade (Grade 2–3) Liposarcoma of the Extremity or Superficial Trunk

This page outlines the evidence-based approach for localised, clinically resectable, high-grade (grade 2–3) liposarcoma arising in the extremity or superficial trunk — a setting where locoregional control and, in selected patients, systemic therapy are central to management.

Clinical Scenario

Localised, clinically resectable soft-tissue sarcoma of the extremity or superficial trunk, histologically confirmed as high-grade (grade 2–3) liposarcoma. Achieving adequate local control while preserving function is the primary clinical objective.

Treatment Approach (Partial Overview)

Wide surgical excision combined with radiotherapy is the standard approach for high-grade (grade 2–3) lesions. In fit patients assessed to be at elevated risk, additional systemic treatment may be integrated into the overall plan.

Full regimen details, treatment sequencing, and patient selection criteria are available in the complete structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.annonc.2021.07.006

Localised, clinically resectable, extremity and superficial trunk STS
Grade 2-3
Wide excision and RT are the standard treatment of high-grade (G2-3) lesions [II, B].
RT is typically added to surgery as part of the standard treatment of high-grade (G2-3) lesions [II, B].
Adjuvant/neoadjuvant AI ChT for at least three cycles can be proposed to patients at high risk of death [II, B].

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