Leukemia cutis presenting in the context of chronic neutrophilic leukemia (CNL) represents a specific and clinically challenging scenario. The skin involvement reflects systemic disease in a rare myeloproliferative condition.
Chronic neutrophilic leukemia is a rare BCR-ABL negative myeloproliferative leukemia characterised by accumulation of mature neutrophils. When leukemia cutis develops in this setting, management must account for the underlying CNL biology and its limited treatment landscape.
For eligible patients, the treatment approach involves a transplant-based strategy — however, patient-specific factors, disease status, and donor availability determine the full protocol. The complete regimen, eligibility criteria, and sequencing are detailed in the structured protocol.