Treatment of Leukemia Cutis in Chronic Neutrophilic Leukemia

Clinical Scenario

This protocol addresses leukemia cutis arising specifically in the context of chronic neutrophilic leukemia (CNL) — a rare BCR-ABL negative myeloproliferative neoplasm. Skin involvement in CNL represents extramedullary leukemic infiltration and is managed within the framework of the underlying systemic disease.

Underlying Condition

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative BCR-ABL negative leukemia characterised by marked accumulation of mature neutrophils. Its rarity and distinct biology directly inform how leukemia cutis in this setting is approached.

Treatment Approach

Management is directed at the underlying CNL. A conventional frontline systemic agent represents the established initial approach, and targeted therapy may have a role in selected patients. The complete regimen — including agent selection, sequencing, and the role of further interventions — is detailed in the full protocol.

Full regimen, decision algorithm, and clinical criteria available in the structured protocol below.