Leukemia cutis represents a rare cutaneous manifestation of acute lymphoblastic leukemia (ALL). When it does occur in this setting, it raises specific clinical management questions that differ from other leukemic subtypes.
This protocol applies to patients with leukemia cutis arising in the context of acute lymphoblastic leukemia — a presentation seen in only approximately 1% of ALL cases. The rarity of this combination warrants a structured, evidence-based approach.
Treatment strategy is guided by the extent of cutaneous disease and the patient's candidacy for intensive systemic therapy. The approach may involve systemic treatment, transplant-based options, or localised modalities depending on individual eligibility — the complete structured regimen is available via the protocol below.
DOI: 10.3390/cancers15225393