Treatment of Severe Leptospirosis with Renal Failure and Hepatic Failure in Adults

This protocol applies to non-pregnant adults presenting with severe leptospirosis whose course is complicated by concurrent renal failure and hepatic failure — the multi-organ pattern that determines which management pathway is appropriate.

Renal failure and hepatic failure occurring together are the hallmark of severe disease in this population. The presence of acute liver failure alongside renal compromise is a key criterion that shapes the treatment strategy in this protocol.

Management includes antimicrobial therapy administered in parallel with mechanical ventilation, together with early targeted intervention for pulmonary complications. The complete regimen, clinical decision pathway, and full sequencing are available in the structured protocol.

This is a partial overview only. Access the full protocol below for the complete evidence-based regimen.