What is the treatment of latent tuberculosis (LTBI)?

Latent tuberculosis infection (LTBI) represents a state of persistent immune response to Mycobacterium tuberculosis without signs of active disease. Identifying and treating LTBI is a core strategy for preventing progression to active tuberculosis. This protocol addresses first-line antibiotic management of LTBI.

Recommended management involves antibiotic therapy, with isoniazid-based regimens forming the backbone of most approaches. Both monotherapy and combination regimens are among the recognised options.

The complete regimen selection — including all options, criteria for choosing between them, and course details — is available in the full protocol below.