Treatment of Late Vomiting of Pregnancy When Nausea and Vomiting Persists
Late vomiting of pregnancy (ICD-11 JA60.2 / ICD-10 O21.2) involves persistent nausea and vomiting in pregnancy that has not been adequately controlled by initial measures, warranting escalation to structured second-line pharmacotherapy.
Clinical Scenario
Ongoing nausea and vomiting of pregnancy that continues despite earlier management, requiring a defined second-line pharmacological approach.
Treatment Approach (overview only)
Second-line management involves adding a sedating antihistamine to the existing regimen. The complete protocol — including agent selection, route of administration, dosing schedule, and safety parameters — is available in the full guideline.
References
- If nausea and vomiting persists then a second sedating antihistamine should be added.
- 10-25mg tablet orally three to four times per day. Maximum 100mg in 24 hours
- 12.5mg by IM injection three to four times per day