Late vomiting of pregnancy
ICD-10 O21.2 · ICD-11 JA60.2

First-Line Pharmacological Treatment of Late Vomiting of Pregnancy

Late vomiting of pregnancy (ICD-10 O21.2 / ICD-11 JA60.2) is characterised by persistent nausea and vomiting occurring beyond the first trimester. A structured, evidence-based pharmacological approach is indicated when symptoms require active management.

First-line approach: Treatment involves combination pharmacotherapy using Pyridoxine (Vitamin B6) together with Doxylamine, titrated according to patient tolerance. Evidence supports that this combination reduces the severity and duration of nausea and vomiting of pregnancy.

Full dosing schedule, titration steps, and the complete clinical algorithm are in the structured protocol below.
Instant Access to Structured Evidence-Based Regimens

References

Evidence shows that a combination of pyridoxine and doxylamine reduces the severity and duration of NVP in patients with a past history or risk factors for hyperemesis.

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