First-Line Treatment of Kawasaki Disease

Kawasaki disease requires prompt, evidence-based first-line treatment to achieve fever resolution and reduce the risk of complications. The standard approach combines two agents, with the primary measure of success being fever resolution within a defined window after the infusion is complete.

Treatment Goal

Resolution of fever within 36 hours after completion of the initial intravenous infusion.

First-Line Approach

The standard first-line regimen combines intravenous immunoglobulin (IVIG) as a single infusion with concurrent aspirin. Specific dosing tiers, the defined sequence, and complete management algorithm are contained in the full structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1002/art.42041

IVIG is the standard-of-care therapy for the initial treatment of KD.
For patients with acute KD, using aspirin is strongly recommended over no aspirin.
IVIG has been established as the standard-of-care treatment for KD for the last 4 decades due to the significant reduction in the rate of coronary artery aneurysms as well as a reduction in the duration of fever and other symptoms associated with its use.

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